Glucose levels normally may go up with lupus but not necessarily due to the lupus itself. It may go up due to the steroids that a person with lupus may be treated with to help control this auto-immune disease.
In a general case lupus should not affect the blood glucose levels. But the medicines mainly steroid based ones taken on a continuous basis to treat this can affect the glucose levels
Lupus can affect internal organs and blood sugar highs can occur. Cortisone medications that are used for lupus flares can also cause blood sugar to rise. Repeated use of cortisone can cause permanent diabetes.