A puppy may be susceptible to an autoimmune reaction if given a combination of vaccines with modified live viruses. The pup may tolerate the initial vaccine, but experience difficulties of the immune system with subsequent shots. It is most prevalent in Weimaraner puppies.
Autoimmune reaction is the body not recognizing its own healthy tissue and therefore believing it is a foreign antigen such as a virus. Believing it to be a virus etc. causes the body to attack it. It can be a very serious condition and you should consult your vet.
An autoimmune reaction happens when giving a combination on shots to puppies. The puppy will become lethargic feverish, joints may swell and the puppy won't be interested in food.
It is a small alergic reaction, many times it is scary but not life threatening. If you dog is throwing up or acting lethergic try and keep it hydrated and give some nutrical to ensure their blood sugar does not crash.
An autoimmune reaction is a severe, systemic reaction that can be fatal if not quickly treated. Signs include swelling of the face, trouble breathing, fever, etc.
Acute reaction to combination live virus vaccines, auto-immune reaction, sometimes occur in a small number puppies. the subsequent vaccines cause a severe immune system.