Babies should always have their sleep at a routine time. If Babies are sleepless they would be tired and cranky. They wont feel to enjoy with anything around them but they would be crying all the time. Gastric problems may also be a reason for being fussy and not satisfied.
Maybe the baby needs a rest. Turn off any machine that makes noise or vibration. Put your baby in a room that was open for a fresh air and than close the windows, turn down the curtains, feed it well and lay it down in it's bed. Let it sleep for a while.