A mobile home becomes a permanent house once it has been placed on a foundation and has hookups for both water and electric. The differences are minimal, but that's what constitutes the difference.
First, remove the axles and the tongue of the mobile home. Depending on the situation, such as trying to acquire a loan, some lenders require that the home be on a cement block foundation.
To make a mobile home a more perment building most people have them set on blocks and put a skirt around them. There are some who set manufactured homes on a regular foundation also if this is an option for you. Be aware no matter what you do with the home it will always be legally classified as a mobile.