Answer by  
                                                                                          turkworker (1007)
                                                            
                          
                          
                                                          A sprain is an injury to a ligament, a thick, tough, fibrous tissue that connects bones together. The ligaments that are most commonly injured are in the ankle, knee, and wrist.  A strain is an injury to a muscle or tendon.  Muscles move your skeleton and if they are stretched too far, it causes a strain.