Fly into San Fransisco, or Oakland, or San Jose; stay in San Fransisco, explore on foot or by public transportation; rent a car and drive to Pebble Beach and Monterrey; than drive Napa Valley's wine routes.
Napa is a great area to go on Wine tasting tours. There are plenty of vineyards there where you can sample wine including one owned by Francis Ford Copula. Pebble Beach is of course a great place to go to the beach. San Fransisco has good shopping and food. It has a great China Town.