You can play rummy with two people. Also you can do black jack with just two, as well as double solitare and WAR. Quite a few games can be done with only two players, try getting a book of hoyle for other ideas.
There are many Rummy games designed for two people. Do a Google search for Rummy, in order to, get the rules. Also, you might enjoy King on The Corner, which can be researched online for rules, too.
Cribbage, 52 card pickup, Double Solitaire and Gin are the most popular two player card games. Two-player Pinochle and Speed (also called Spit) are two other fast-paced games perfect for two players.