To tell the truth it really depends on what mood I am in. Some days I do prefer Kleenex and other days I rather have Puffs. I can't tell too much of a difference between the two.
I prefer Kleenex to Puffs. I find that kleenex is softer on my nose and my kids sensitive little noses. Also, I find that Puffs have more fuzz on each indivdual tissue.