Africa has a very devise ecosystem that is home to many different animals species that a dangerous to humans. There is a the Black Mamba snake to large cats such as Lions, but it is known the most dangerous animal in Africa is the Hippopotamus. Hippopotamuses display unpredictable behavior which is one of the many reasons their are so dangerous.
To be honest, human. Human beings are animals, after all, and we are considered a super predator on every continent. After humans, I would say the tigers of Africa.