There are great individual differences in the effects of these antidepressant drugs, and the effective dose varies widely from one patient to the next. Elderly people may be more sensitive to
these drugs because their livers are not as efficient in metabolizing them, and therefore could need lower doses instead.
There are not specific antidepressants targeted towards the geriatric population, but there are specific dosages recommended for geriatric patients whose renal function may not be optimal.